人乳牙牙髓干细胞在干细胞治疗中的应用

doi:10.7518/hxkq.2017.05.017

摘要/Abstract

摘要：

乳牙牙髓干细胞（SHED）是牙源性干细胞的一种,属外胚间充质干细胞。作为一种理想的干细胞来源,SHED在干细胞治疗中有良好的应用前景。本文阐述了SHED的生物学特征及其在干细胞治疗中的优势,探讨了SHED在组织再生和修复中发挥的多向分化潜能、细胞分泌功能和免疫调节功能等方面的功能作用。此外,本文还介绍了SHED在各系统、器官疾病治疗中的临床应用,重点阐述了用SHED进行干细胞移植在牙髓—牙本质再生、颌骨再生、神经系统疾病治疗和免疫系统疾病治疗方面的研究进展。

关键词: 人乳牙牙髓干细胞, 干细胞治疗, 临床应用

Abstract:

Stem cells from human exfoliated deciduous teeth (SHED) are one category of dental stem cells. They belong to ectodermal mesenchymal stem cells. As an ideal stem cell source, SHED possess great potential in stem cell therapy. This review demonstrates the biological characteristics and advantages of SHED in stem cell therapy and discusses its multiple functions in tissue regeneration and repair, including multiple differentiation potentiality, cell secretion of cytokines, and immunomodulatory ability. Furthermore, this article introduces the main findings regarding the potential clinical applications of SHED to a variety of diseases. This article demonstrates research progress in dentin-pulp regeneration, maxillofacial bone regeneration, and treatment of nervous system and immune system diseases with SHED for stem cell transplantation.

Key words: stem cells from human exfoliated deciduous teeth, stem cell therapy, clinical applications

中图分类号:

R780.2

李晓霞, 方滕姣子, 余湜, 赵玉鸣, 葛立宏. 人乳牙牙髓干细胞在干细胞治疗中的应用[J]. 华西口腔医学杂志, 2017, 35(5): 533-537.

Xiaoxia Li, Jiaozi Fangteng, Shi Yu, Yuming Zhao, Lihong Ge. Clinical applications of stem cells from human exfoliated deciduous teeth in stem cell therapy[J]. West China Journal of Stomatology, 2017, 35(5): 533-537.

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